Titanium Functionalized Bioactive Implants with Intelligent Antibiotic Systems
Domaine Santé et Bien-être
Technologie Matériaux avancés et actifs
Applications
- Preventionand/or treatment of prosthesis related infection in
- Orthopedic joint replacement
- Spine surgery
Challenges
Prosthesis related infection is a serious complication for patients, which is currently difficult to treat with classical antibiotic therapy Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection.
Description
This project aims to develop orthopedic implants based on titanium functionalized with intelligent antibiotic systems Antibiotic release systems (widely used to prevent infections during orthopedic surgery are controlled by a change in pH on bone implants typically observed in bacterial infections.
Benefits
- In site controlled delivery of antibiotics
- Materials bifunctionalization with gentamicin and vancomycin
- All titanium prosthesis could be coated
- Hospital costs reduction
- Extension to the local delivery of factors capable of regulating the relationship between an implant and the tissues surrounding it
Maturation
Maturation with Aquitaine Science Transfert showed the possibility of synthesizing bioactive implants allowing the release of an antibiotic only in case of infection
Inventeurs
Marie-Christine DURRIEU
Damien QUEMENER
Laboratoire de Chimie des Polymères
Organiques LCPO, UMR 5629)
Valérie HEROGUEZ
Hélène CARRIÉ
Loïc PICHAVANT
Institute of Chemistry and Biology
of Membranes and Nano objects
(CBMN, UMR 5248 )
Propriété intellectuelle
Patent applications WO 2016 097358 A 1 WO 2006 008386 A 1 WO 2006 008387 A 1
Contact
Carlos LARRAYA
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Jean Luc CHAGNAUD
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