New Lipophilic Formulation of α-Tocopherol
Domaine Santé et Bien-être
Technologie Non renseignée
CHALLENGES
Topically applied vitamin E α-tocopherol can inhibit UVR-induced DNA damage. However, α-tocopherol has several limitations including poor photostability and poor topical formulation solubility due to its hydrophobicity. Retention in the stratum corneum is also a limitation.
INNOVATIVE SOLUTION
New lipophilic formulation of α-tocopherol coupled to a nucleolipid through an ester.
Applications
- Cosmetic : anti-UV cream
- Ophthalmology
Advantages
- Bio-inspired, biocompatible, biodegradable
- Lipophilic
- Stable : not photo-sensitive
- Sustained release
- Better protection against UVA exposure and ROS
- Cheap raw materials
HOW IT WORKS
The prodrug developed consists of a nucleolipid part and an antioxidant one (α-tocopherol for example). The active ingredient is therefore released only under the action of esterases present in the epidermis or in corneal epithelium, which ensures its photostability.
Its incorporation into sunscreen or ophtalmologic formulations would be particularly relevant, as it is activated by the sun (UVs).
If necessary, it can also be dispersed in a nano emulsion to ensure not only slow diffusion but also better passage of biological barriers.
Inventeurs
Developed by a research team : ARNA
Propriété intellectuelle
FR 2105088 « Antioxidant nucleolipid prodrug, pharmaceutical composition for its administration and therapeutic uses thereof »
PARTERSHIPS
License and/or R&D collaboration (Possible Co-funding)
Contact
Carlos LARRAYA
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+33 (0)6 18 40 63 51
