OLIGONUCLEOTID TABLETS: Process to formulate oligonucleotids into tablets for an oral administration
Domain Health and wellbeing
Technology Microfluidics
Applications
- New galenic formulation for therapeutic approach based on oligonucleotids
- Tablets suitable for siRNA, shRNA, miRNA, mRNA and RNAi
- Oral administration of biological active molecules
Description
- Patented process to compress into tablets the oligonucleotids while maintaining their therapeutic activity
- Compatible with large panel of encapsulated vectors
- Possibility to combine the approach with the well known process to control the delivery
- Combination of multiple therapeutic oligonucleotids in a single tablet
Benefits
- Opens new perspectives for simple use of therapeutic oligonucleotids
- Obtention of sterilized, stable, easy to store tablets
- High patient compliance expected
Inventors
Pierre TCHORELOFF
Virginie BUSIGNIES-GODDIN
Institut de Mécanique et d’Ingénierie de Bordeaux (I2M, UMR 5295)
Team: Galenics – Mechanics of Compacted Pharmaceutical Powders
Virginie ESCRIOU
Pascal BIGEY
Christine CHARRUEAU
Laboratory of “Chemical and Biological Technologies for Health” (Paris, UTCBS, UMR 8258, U 1022)
Contact
Jean-Luc CHAGNAUD
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